Medicinal Chemistry

Dimitra Hadjipavlou-Litina
Aristotle University of Thessaloniki
Thessaloniki
Greece

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Additive Effect of MCP in Combination with Cefotaxime Against Staphylococcus aureus

(E-pub Ahead of Print)

Author(s): Elias Dahdouh, Salah El-Khatib, Elias Baydoun, Roula M. Abdel-Massih.

Abstract:

Background: Pectin is a heterogeneous polysaccharide present in plants and citrus fruits. It exhibits different beneficial biological activities. Conflicting reports exist about the antimicrobial effect of pectin and its derivatives.

Objective: In this study, we investigate the antimicrobial effect of Modified Citrus Pectin (MCP) against Staphylococcus aureus, a pathogen showing increasing rates of antimicrobial resistance worldwide.

Methods: Forty-three clinical isolates of S. aureus were obtained from a hospital in North Lebanon. Minimum Inhibitory Concentrations (MICs) and Minimum Bactericidal Concentrations (MBCs) were determined using MCP after determining its optimum pH activity. The combination between MCP and cefotaxime was then investigated for S. aureus isolates using the checkerboard technique.

Results and Discussion: The optimum pH for the activity of MCP was 6.0. MIC and MBC values against S. aureus ranged between 0.39–50 μg/μl and 3.13–50 μg/μl, respectively. These values are promising for using MCP in the inhibition of some S. aureus isolates at relatively low concentrations. Combination experiments showed an additive effect in most S. aureus strains between MCP and cefotaxime, and a synergistic effect in two strains. These preliminary findings open the way for further investigation into the therapeutic potential of MCP in the treatment of S. aureus infections.

Conclusions: MCP demonstrates in vitro antimicrobial activity alone and in combination with cefotaxime against S. aureus.

Keywords: Staphylococcus aureus, Modified Citrus Pectin, Checkerboard, Antibiotic Resistance, MRSA, Combination therapy.

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Article Details

VOLUME: 13
Year: 2017
(E-pub Ahead of Print)
DOI: 10.2174/1573406413666170306112444
Price: $95