In 1863, Diphenylamine (DPA) was prepared by Hoffmann by the destructive distillation of
different triphenylmethane dyes. DPA are naturally occurring compounds, present in onions, leaves of
black and green tea and peel of citrus fruits. DPA derivatives belong to the category of Non Steroidal
Anti-inflammatory Drugs (NSAIDs). Diclofenac, chemically called 2-(2,6-dichloranilino) phenylacetic
acid, is a well-known NSAID. Other important compounds are tolfenamic acid, flufenamic acid and
mefenamic acid, etc. DPA derivatives are claimed for several important biological activities which
include anti-microbial, analgesic, anti-inflammatory, anti-convulsant and anti-cancer activities. Many
more compounds have been discovered and many are still being focused.
The key goal of this article is to show up the different derivatives and the pharmacological activities of
DPA. Hence, it can be concluded that DPA and its derivatives possess significant therapeutic functions
and many potent derivatives are still to be discovered.