Background: In consideration of recent developments in understanding the genomics and proteomics
of viruses, the use of viral DNA / RNA sequences as well as their gene expression schemes, have found
new in-roads towards the prognosis and therapy of diseases. Correspondingly, the sphere of the patenting scenario
has expanded significantly.
Objectives: The current review addresses patented inventions concerning the use of virus sequences as gene silencing
machineries and inventions concerning the generation and application of viral sequences as expression
vectors. Furthermore, this review also discusses the employment of these patents for clinical, agricultural and
Method: Considering these objectives, the Delphion Research Intellectual Property Network database was
searched using keywords such as “gene silencing”, “engineered viruses” and “expression vectors” and descriptions
of recent patents on the said topics were discussed.
Conclusion: Despite several recent advances in the use of viruses as disease therapy vehicles and biotechnological
vectors, these developments have yet to be proven effective in practice, in clinical and field trials.