Advance in Anti-tumor Mechanisms of Shikonin, Alkannin and their Derivatives

Author(s): Xu Zhang, Jia-Hua Cui, Qing-Qing Meng, Shao-Shun Li, Wen Zhou*, Sui Xiao*.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 2 , 2018

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Abstract:

Shikonin, alkannin and their derivatives, the main ingredient of Lithospermum erythrorhizon and Arnebia euchroma (Royle) Johnst native to Inner Mongolian and Northwest of China respectively, hold promising potentials for antitumor effects via multiple-target mechanisms. This review will emphasize the importance of their antitumor activity in apoptosis, necroptosis and immunogenic cell death, and expound the relationship of their antitumor activity and naphthoquinone scaffold that could generate ROS and alkylating agent. Meanwhile, the antitumor mechanisms of naturally-occurring shikonin, alkannin and their derivatives, which were divided into the direct interaction involved in alkylating agent, covalently binding the DNA and protein, as well as the indirect interaction mediated by ROS, nonspecifically influencing the mitochondria or multiple signal pathways, will be systematically summarized and discussed.

Keywords: Alkannin, anti-tumor mechanisms, bioalkylation, DNA, ROS, shikonin.

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Article Details

VOLUME: 18
ISSUE: 2
Year: 2018
Page: [164 - 172]
Pages: 9
DOI: 10.2174/1389557517666170228114809
Price: $58

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