Background: Thiazole derivatives are known as important sulfur containing heterocycles
which are present in a wide range of biologically active natural products.
Methods: A series of thiazolone derivatives were synthesized and evaluated for their soybean 15-LOX
inhibitory activity. The title compounds were prepared by the reaction of 2-arylthiazol-4(5H)-ones and
different aromatic aldehydes. All compounds were characterized and evaluated against soybean 15-LOX.
Results: Among the synthesized thiazolone derivatives, 5-(4-methoxybenzylidene)-2-((2-methoxyphenyl)
amino)thiazol-4(5H)-one (3l) was found to be the most active compound comparing with quercetin as the
Conclusion: It seems that prepared thiazolones having methoxy groups both on aryl and aminoaryl
moieties can be considered for further drug discovery research.