CRH Receptors in Human Reproduction

Author(s): Antonis Makrigiannakis*, Thomas Vrekoussis, Emmanuel Zoumakis, Iordanis Navrozoglou, Sophia N. Kalantaridou.

Journal Name: Current Molecular Pharmacology

Volume 11 , Issue 1 , 2018

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Graphical Abstract:


Background: Corticotropin releasing hormone (CRH), the main peptide-mediator of stress, has been found in the female reproductive system.

Objective: Herein, the role of CRH receptors in the female reproductive system is presented.

Results: It is clear that CRH receptors are involved in the regulation of the hypothalamic-pituitaryovarian axis, while locally are associated with decidualization, embryonic implantation, early fetal development and triggering of parturition.

Conclusion: Abnormal CRH signaling may contribute to obstetrical pathophysiology, such as preeclampsia, abnormal placenta invasion, endometrial growth retardation and preterm delivery.

Keywords: CRH receptors, ovary, implantation, fetal immunotolerance, receptivity, parturition.

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Article Details

Year: 2018
Page: [81 - 87]
Pages: 7
DOI: 10.2174/1874467210666170224094146
Price: $58

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