Natural antineoplastic drug development is crucial to treatment of clinical oncology. Dihydromyricetin,
a bioactive flavonoid compound was extracted from the stems and leaves of Ampelopsis
grossedentata. It exhibited anticancer activity and induced apoptosis in human hepatocellular
carcinoma cells according to our previous studies. In this study, we demonstrated that DHM could
significantly inhibit proliferation and induce apoptosis in HepG2 cells with MTT and Flow Cytometry
methods. It is very interesting that we found DHM could regulate TGF-β signal pathway and
which has a crosstalk with P53, Smad3 and P-Smad2/3 proteins. Meanwhile, we confirmed that
DHM showed antitumor activity by regulating the activation of the p53-dependent pathways
(MDM2, P-MDM2, BAX and Bcl-2). These findings defined and supported a novel mechanism that
DHM could induce cell apoptosis by reducing TGF-β via p53 signal pathway in HepG2 cells.
Keywords: Dihydromyricetin, anti-cancer, proliferation, apoptosis, P53, hepatocellular carcinoma.
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