Abstract
Oncolytic viruses, which include both naturally occurring wild-type viruses/attenuated viruses and genetically modified viruses, have recently been developed for use in innovative cancer therapies. Genetically modified oncolytic viruses possess the unique ability to replicate conditionally as a unique gene therapy product. Since oncolytic viruses exhibit prolonged persistence in patients, viral shedding and transmission to third parties should be major concerns for clinical trials along with the clinical safety and efficacy. Accordingly, studies are now underway to establish the safety and efficacy of oncolytic viruses.
Keywords: Oncolytic virus, gene therapy, cancer therapy, replicating virus, genetically modified viruses, clinical safety and efficacy.
Current Cancer Drug Targets
Title:Oncolytic Virus: Regulatory Aspects from Quality Control to Clinical Studies
Volume: 18 Issue: 2
Author(s): Teruhide Yamaguchi*Eriko Uchida
Affiliation:
- Department of Pharmaceutical Sciences, Nihon Pharmaceutical University, Saitama,Japan
Keywords: Oncolytic virus, gene therapy, cancer therapy, replicating virus, genetically modified viruses, clinical safety and efficacy.
Abstract: Oncolytic viruses, which include both naturally occurring wild-type viruses/attenuated viruses and genetically modified viruses, have recently been developed for use in innovative cancer therapies. Genetically modified oncolytic viruses possess the unique ability to replicate conditionally as a unique gene therapy product. Since oncolytic viruses exhibit prolonged persistence in patients, viral shedding and transmission to third parties should be major concerns for clinical trials along with the clinical safety and efficacy. Accordingly, studies are now underway to establish the safety and efficacy of oncolytic viruses.
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Cite this article as:
Yamaguchi Teruhide*, Uchida Eriko, Oncolytic Virus: Regulatory Aspects from Quality Control to Clinical Studies, Current Cancer Drug Targets 2018; 18 (2) . https://dx.doi.org/10.2174/1568009617666170222142650
DOI https://dx.doi.org/10.2174/1568009617666170222142650 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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