Abstract
Background: The endothelium is a large paracrine organ regulating cell growth, vascular tone and thrombogenicity as well as platelet and leukocyte interactions. Endothelial function can be assessed by noninvasive techniques [e.g. flow-mediated vasodilation, nitroglycerin-mediated dilation and pulse wave velocity] and measuring specific circulating biomarkers [cell adhesion molecules, endothelial microparticles and endothelial progenitor cells]. Impaired endothelial function plays a key role in the development of atherosclerosis, arterial hypertension, heart failure, ischemia-reperfusion injury, Alzheimer’s disease and other conditions. Endothelial function is also involved in growth and proliferation of tumor cells.
Methods: We performed a literature review and assessed the role of the natural polyphenol, curcumin, as a potential inexpensive, well-tolerated, and safe agent for improving endothelial function. Results: Curcumin exerts several positive pharmacological effects; these include anti-inflammatory, antioxidant, anti-hypertensive, anti-cancer, antiviral, anti-infective and wound-healing properties. Specifically, curcumin’s anti-inflammatory effects are thought to be caused by reducing trans-endothelial monocyte migration by reduction of mRNA and protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin and by modulating NFκB, JNK, p38 and STAT-3 in endothelial cells. Dietary curcumin supplementation can also increase antioxidant activity through the induction of heme oxygenase-1, a scavenger of free radicals, and by reduction of reactive oxygen species and Nox-2. Conclusions: Curcumin appears to improve endothelial function but additional research is needed to determine the precise mechanism(s) and biomarkers involved in curcumin’s therapeutic effects on endothelial dysfunction.Keywords: Curcumin, endothelial function, flow-mediated vasodilation, nitroglycerin-mediated dilation, pulse wave velocity, adhesion molecules.
Current Pharmaceutical Design
Title:Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects
Volume: 23 Issue: 17
Author(s): Maryam S. Karimian, Matteo Pirro, Thomas P. Johnston, Muhammed Majeed and Amirhossein Sahebkar*
Affiliation:
- Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, P.O. Box: 91779-48564,Iran
Keywords: Curcumin, endothelial function, flow-mediated vasodilation, nitroglycerin-mediated dilation, pulse wave velocity, adhesion molecules.
Abstract: Background: The endothelium is a large paracrine organ regulating cell growth, vascular tone and thrombogenicity as well as platelet and leukocyte interactions. Endothelial function can be assessed by noninvasive techniques [e.g. flow-mediated vasodilation, nitroglycerin-mediated dilation and pulse wave velocity] and measuring specific circulating biomarkers [cell adhesion molecules, endothelial microparticles and endothelial progenitor cells]. Impaired endothelial function plays a key role in the development of atherosclerosis, arterial hypertension, heart failure, ischemia-reperfusion injury, Alzheimer’s disease and other conditions. Endothelial function is also involved in growth and proliferation of tumor cells.
Methods: We performed a literature review and assessed the role of the natural polyphenol, curcumin, as a potential inexpensive, well-tolerated, and safe agent for improving endothelial function. Results: Curcumin exerts several positive pharmacological effects; these include anti-inflammatory, antioxidant, anti-hypertensive, anti-cancer, antiviral, anti-infective and wound-healing properties. Specifically, curcumin’s anti-inflammatory effects are thought to be caused by reducing trans-endothelial monocyte migration by reduction of mRNA and protein expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and P-selectin and by modulating NFκB, JNK, p38 and STAT-3 in endothelial cells. Dietary curcumin supplementation can also increase antioxidant activity through the induction of heme oxygenase-1, a scavenger of free radicals, and by reduction of reactive oxygen species and Nox-2. Conclusions: Curcumin appears to improve endothelial function but additional research is needed to determine the precise mechanism(s) and biomarkers involved in curcumin’s therapeutic effects on endothelial dysfunction.Export Options
About this article
Cite this article as:
Karimian S. Maryam, Pirro Matteo, Johnston P. Thomas, Majeed Muhammed and Sahebkar Amirhossein*, Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects, Current Pharmaceutical Design 2017; 23 (17) . https://dx.doi.org/10.2174/1381612823666170222122822
DOI https://dx.doi.org/10.2174/1381612823666170222122822 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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