Amino-functional Silsesquioxanes (POSS)-Effective Glass Surface Modifiers in Solidphase Nucleic Acid Synthesis

Author(s): Karol Szubert , Marta Piepiorka , Magdalena Jankowska-Wajda , Jolanta Brzezinska , Karol Pasternak , Natalia Remszel , Emilia Frydrych-Tomczak , Hieronim Maciejewski , Marcin K. Chmielewski* .

Journal Name: Current Organic Chemistry

Volume 21 , Issue 25 , 2017

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Abstract:

Branched amino functional polyoctahedral silsesquioxanes (POSS) were prepared by using different stoichiometric ratios of two olefins: allylamine and vinyltrimethoxysilane. Amino-rich CPG particles were produced by direct silanisation with amino-POSS silanes. The parameters of surface morphology (total volume and size of pores) of the obtained supports were determined by Brunauer-Emmett-Teller method. Results from Scanning Electron Microscopy show that there is no alteration in surface chemistry and only modest changes in mechanical properties are detected. The POSS-modified CPG supports were demonstrated as effective scaffolds for the chemical synthesis of nucleic acids.

Keywords: Silsesquioxane, solid-phase synthesis, nucleic acids, RNA or DNA synthesis, solid supports, scanning electron microscopy.

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Article Details

VOLUME: 21
ISSUE: 25
Year: 2017
Page: [2597 - 2604]
Pages: 8
DOI: 10.2174/1385272821666170222111024
Price: $58

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