Branched amino functional polyoctahedral silsesquioxanes (POSS) were prepared by using different
stoichiometric ratios of two olefins: allylamine and vinyltrimethoxysilane. Amino-rich CPG particles were
produced by direct silanisation with amino-POSS silanes. The parameters of surface morphology (total volume
and size of pores) of the obtained supports were determined by Brunauer-Emmett-Teller method. Results from
Scanning Electron Microscopy show that there is no alteration in surface chemistry and only modest changes
in mechanical properties are detected. The POSS-modified CPG supports were demonstrated as effective scaffolds
for the chemical synthesis of nucleic acids.
Keywords: Silsesquioxane, solid-phase synthesis, nucleic acids, RNA or DNA synthesis, solid supports, scanning electron microscopy.
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