The incidence of Tuberculosis (TB) is baffling in developing countries due to the increase in
multidrug-resistant and extensively drug-resistant TB. Therefore, drugs acting through different
mechanisms are in dire need to counter the resistant strains. Various chemical scaffolds are being investigated
against tuberculosis, among them the molecules containing phenothiazine nucleus are found
to be more effective against both susceptible and resistant strains of M. tuberculosis. In addition, the
efficacy of first-line drugs has been found to be enhanced on supplementary treatment with phenothiazines.
The present review provides an overview of the phenothiazine based molecules which were investigated
during the last ten years for their anti-tubercular activity.
Keywords: Phenothiazine, psychotropic, repurposing, resistance, SAR, tuberculosis.
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