Combinatorial Chemistry & High Throughput Screening

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A novel protein characterization based on Pseudo Amino Acids composition and Star-like graph topological indices

(E-pub Abstract Ahead of Print)

Author(s): Qi Dai, Hong Tao, Tingting Ma, Yuhua Yao, Pingan He.

Abstract:

In the work, a new description of proteins based on five topological indices of star-like graph representation and the occurrence frequency of 20 amino acids was proposed to compare the similarities of proteins. A phylogenetic tree of eight ND6 proteins was constructed to demonstrate the effectiveness and rationality of our approach. Analogously, we applied this method to RNA polymerase proteins of some subtypes of influenza virus to infer their phylogenetic relationship. The results showed that the phylogenetic relationship among RNA polymerase of influenza virus is closely related to distributions of species virus host and geographical distribution.

Keywords: RNA polymerase, star-like graph, Pseudo Amino Acids composition, phylogenetic tree, alignment-free, topological indices

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Article Details

VOLUME: 20
Year: 2017
(E-pub Abstract Ahead of Print)
DOI: 10.2174/1386207320666170217152811
Price: $95