Advances in Modern Medicine

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Advances in Modern Medicine introduces recent advanced medical practices performed at the Kure Medical Center and Chugoku Cancer Center (KMCCCC) - one of the leading hospitals in Japan - to those ...
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Humanized Mouse Models as An Experimental Tool to Investigate Disease Immunology

Pp. 390-401 (12)

Takashi Onoe

Abstract

Many studies of human immunology have been limited to ex vivo analysis due to ethical considerations. Detailed study, however, requires in vivo analysis, as ex vivo analysis of human immune cells does not always represent in vivo status. Therefore, small animal models have been used to overcome this limitation and several humanized mouse models that reproduce the human immune system have been developed. This review summarizes humanized mouse model characteristics and progress in their use for research of human diseases immunology.

Keywords:

Humanized mouse model, Immunodeficient mouse, Immunology, Pre-clinical research, Translational research.

Affiliation:

Institute for Clinical Research, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure 737-0023, Japan.