Advances in Modern Medicine

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Advances in Modern Medicine introduces recent advanced medical practices performed at the Kure Medical Center and Chugoku Cancer Center (KMCCCC) - one of the leading hospitals in Japan - to those ...
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Topics in Neurology

Pp. 273-286 (14)

Tsuyoshi Torii

Abstract

Over the last decade there have been many advances in neurology. This article reviews topics in neurology, specifically for stroke and neurodegenerative diseases. Advances in magnetic resonance imaging provide a powerful tool for diagnosing stroke and thrombolysis by alteplase and have facilitated a paradigm shift in the approach to super-acute phase ischemic stroke. Secondary prevention of ischemic stroke has changed in terms of both anti-platelet therapy and anti-coagulation therapy. Over the last decade, understanding about the etiology and pathogenesis of many neurodegenerative diseases has progressed. Recent reports are reviewed here regarding Alzheimer’s disease, Parkinson disease, dementia with Lewy bodies, motor neuron disease and frontotemoral dementia as they share many common mechanisms involving aggregation and accumulation of proteins.

Keywords:

Neurocognitive disorders, Neurodegenerative diseases, Novel oral anticoagulation agents, Stroke, Thrombolysis.

Affiliation:

Department of Neurology, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure 737-0014, Japan.