Advances in Electroconvulsive Therapy for Psychiatric Disorders
Pp. 233-241 (9)
Chiyo Shibasaki and Minoru Takebayashi
We reviewed the history of electroconvulsive therapy (ECT) around the
world and in Japan. Although the practice of ECT began in Japan at around the same
time as the discovery of ECT in the world, improvements in anesthetics and ECT
devices in Japan have not progressed at a similar pace in comparison with that of the
world. Recently, a brief pulse device was approved for use in Japan and ECT practice
guidelines were established. ECT has been recently reevaluated and an ECT network
has been extended in Japan.
Specifically, we offer here a history of ECT and clinical and biological research
findings for ECT from the Kure Medical Center. In 2013, our center conducted nearly
500 ECT sessions with approximately 40 individuals who had mood disorders,
schizophrenia or Parkinson disease. Research on ECT has shown that several factors
are important in recovery. For example, a strategy that includes a dosage of stimulation
energy or reduction of anesthetic might be effective for ECT treatment. Mood
stabilizers such as lithium may be effective in preventing relapse after ECT, not only in
mood disorders, but also for schizophrenia. In addition, cerebral blood flow evaluation
using near-infrared spectroscopy and blood markers such as matrix metalloproteinases
may be related to diagnosis and the course of ECT treatment.
Biological research, Clinical research, Electroconvulsive therapy,
Department of Psychiatry, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure 737-0023, Japan.