Advances in Modern Medicine

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Advances in Modern Medicine introduces recent advanced medical practices performed at the Kure Medical Center and Chugoku Cancer Center (KMCCCC) - one of the leading hospitals in Japan - to those ...
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Clinical Application on Telomere Biology for Cancer

Pp. 139-149 (11)

Toshihiro Matsuo, Hiroki Hachisuka, Takahiko Hamasaki, Yasunori Izuta and Norikazu Hamada

Abstract

Telomere dynamics have been reported extensively as a critical component of cancer, and established evidence exists an important relationship between telomere biology and cancer. Although more than 85% of all carcinomas rely on telomerase activity to maintain stable telomere length, most normal somatic cells are telomerase negative. Therefore, effective methods for specific diagnostic and prognostic utility by telomerase detection have been described, and, to date, ideal targeting telomerase therapy with minimal adverse effects on normal somatic cells have been attempted. In this mini review, we summarize the role of telomeres and telomerase in cancer, clinical use, and targeted telomerase cancer therapies.

Keywords:

Adverse effects, Cancer, Sarcoma, Telomerase, Telomere.

Affiliation:

Department of Orthopaedic Surgery, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1 Aoyama-cho, Kure 737-0023, Japan.