Title:Gastroprotective Effect of Stress Preconditioning: Involvement of Glucocorticoids
VOLUME: 23 ISSUE: 27
Author(s):Ludmila Filaretova*
Affiliation:Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg 199034
Keywords:Preconditioning, stress, gastric mucosa, injury, gastroprotection, glucocorticoids.
Abstract:Stress plays a leading role in maintaining the physical health of the body. Various health effects of
preconditioning mild stress strongly confirm this statement. Preconditioning mild stress, which is everyday event
of animal and human life, may attenuate the development and aggravation of diseases including such widespread
pathology as gastric ulceration. Preconditioning mild stress may diminish gastric injury formation caused by
severe stress. Gastroprotective influence of preconditioning mild stress is known to be mediated by prostaglandins.
In the present article, we focus on the data suggesting that glucocorticoids released in response to preconditioning
mild stressor are important players of gastroprotective influence of preconditioning stress.
