Engineered Muscle Tissues for Disease Modeling and Drug Screening Applications | BenthamScience


Engineered Muscle Tissues for Disease Modeling and Drug Screening Applications

Author(s): Mohammad Hossein Mohammadi, Raquel Obregón, Samad Ahadian, Javier Ramón-Azcón*, Milica Radisic*.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 20 , 2017

Abstract:

Animal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, low physiological similarity to humans, and ethical problems. Engineered tissue models have recently emerged as an alternative or substitute for animal models in drug discovery and testing and disease modeling. In this review, we focus on skeletal muscle and cardiac muscle tissues by first describing their characterization and physiology. Major fabrication technologies (i.e., electrospinning, bioprinting, dielectrophoresis, textile technology, and microfluidics) to make functional muscle tissues are then described. Finally, currently used muscle tissue models in drug screening are reviewed and discussed.

Keywords: Cardiac muscle, Skeletal muscle, drug screening, Engineering muscle, Human pharmacological response, physiological similarity.

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Article Details

VOLUME: 23
ISSUE: 20
Year: 2017
Page: [2991 - 3004]
Pages: 14
DOI: 10.2174/1381612823666170215115445
Price: $58

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