Background: Hydrazonoyl halides are useful for the synthesis of several heterocyclic derivatives.
Thiadiazoles are a significant category of heterocyclic organic compounds with comprehensive range of
Method: New bisthiadiazoles were prepared by the reaction of hydrazonoyl derivatives with methyl-2-
arylidene hydrazinecarbodithioates in dioxane and in the presence of triethylamine. The synthetic method involves
nucleophilic substitution reactions via intramolecular cyclization reactions followed by evolving
methanethiol gas. The new synthesized compounds were identified by elemental analysis and various spectral
data. The antioxidant strength of the synthesized thiadiazoles was explored, utilizing different established in
vitro methods, such as DPPH, superoxide dismutase –like and ABTS scavenging activities.
Results: The antioxidant activities of the synthesized thiadiazoles were apparent as it presented significant reducing
power, superoxide dismutase like ability, ABTS and DPPH-scavenging activities. Furthermore, the antimicrobial
activities and the MIC values of the new thiadiazoles were evaluated against both Gram-negative
and Gram-positive microorganisms. The thiadiazoles 4a, 4b and 4d displayed a substantial nuclease like activities
on the chromosomal DNA.
Conclusion: In the present work, we synthesized a novel series of bisthiadiazole derivatives. Thiadiazoles were
verified for their antimicrobial efficiency against various bacterial strains. In addition, the antioxidant activates
for these compounds to scavenge free radicles were examined using DPPH, ABTS and SOD- like activities.
DNA binding and degradation efficiency for these compounds were examined.