Osteosarcoma is the most frequent primitive malignant bone tumor affecting adolescents and young
adults worldwide. The tumor exhibits aggressive growth in the primary site and readily metastasizes to other
organs. There has been no significant improvement in the 5-year survival rate since the 1970s and the figure
remains at 60–70%. In addition, the side effects of chemotherapeutic drugs and resistance to chemotherapy compromise
the effects of treatment for osteosarcoma. In recent years, the development of flavonoids drugs inhibiting
carcinogenesis is attracting great interest in the scientific community. Flavonoids are one kind of polyphenolic
compounds widely found in vegetables and fruits. Moreover, flavonoids have become popular compounds, exhibiting
comprehensive antitumor activities, while being safe and inexpensive. Here, the literature on the benefits
afforded by flavonoids in terms of osteosarcoma treatment is reviewed and certain flavonoids and their effects on
osteosarcoma are discussed. These compounds can perturb the cell cycle, induce apoptosis, inhibit tumor cell
invasion and metastasis, potentiate the actions of chemotherapeutic agents, trigger autophagy, and stimulate antitumor
activity in vivo. In summary, we highlight the currently well-accepted flavonoid compounds and detail the
molecular mechanisms by which flavonoids may treat osteosarcoma, and thus the flavonoids exhibit great promise
as anti-osteosarcoma agents.
Keywords: Flavonoids, osteosarcoma, cell cycle, apoptosis, metastasis, autophagy, antitumor.
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