Introduction: Astronium fraxinifolium (Anarcadiaceae) is used in folk medicine in
inflammation diseases. This study evaluates the chemical profile as well as antioxidant, antimicrobial,
gastroprotective and wound healing activities of the hydroalcoholic extract of Astronium
fraxinifolium bark (HAAF).
Material and Methods: Phytochemical screening and high-performance liquid chromatography
(HPLC). The antioxidant activity was determined by DPPH (2,2- diphenyl, 1-picrihidrazila) and
FRAP (ferric fraction reductive) methods. The gastroprotective activity was evaluated against
HAAF to classical models of acute gastric: absolute ethanol, acidified ethanol and Indomethacin
(50, 100 and 200mg/kg/orally) and physical barrier mechanism (50mg/kg/orally, intraperitoneally),
used Swiss mice (Mus musculus). The healing activity of HAAF was identified from tissue
shrinkage rate in the control. The antimicrobial activity was observed from the Minimum Inhibitory
Concentration method (MIC) and modulation associated with antibiotics (amikacin, gentamicin,
benzylpenicilin, imipinem + cilastatin sodium, cephalothin, oxalacina and ampicillin) and antifungals
(amphotericin B, nystatin, mebendazole and benzoilmetronidazol).
Results: Phytochemical prospection of Chromatography (HPLC) quantified gallic acid (4.25 %),
chlorogenic acid (2.11%), caffeic acid (0.73%), rutin (0.08 %) and quercetin (0.29%). Measurement
of total flavonoids (0.034 g of quercetin) and phenols (0.538 g of gallic acid) gram of extract
showed significant amount. HAAF showed significant antioxidant potential in DPPH and FRAP
assays. The MIC did not show clinically relevant activity (≥1024 µg/mL). HAAF displayed gastroprotective
different doses (50, 100 and 200 mg/Kg) and Healing activity (100 mg/g).
Conclusion: The results obtained in this study provide biological evidence of the antioxidant
potential, gastroprotective and wound healing effect of the species.