Preparation and Characterization of Silymarin Synchronized and Sustained Release Dropping Pill

Title:Preparation and Characterization of Silymarin Synchronized and Sustained Release Dropping Pill

Volume: 14 Issue: 5

Author(s): Zhi-hong Liu, Xue-jing Li, Ai-wen Huang, Jing Zhang and Hong-tao Song*

Affiliation:

• Department of Pharmacy, Fuzhou General Hospital of Nanjing Command PLA, 156 West Second-Ring Road, Fuzhou, 350025,China

Keywords: Bioavailability, dropping pills, silymarin, sustained release, synchronized release, solid dispersion technique.

Abstract: Purpose: This study aimed to develop a synchronized and sustained-release silymarin dropping pill, and to evaluate its pharmacokinetic characteristics.

Method: Polyoxyethylene stearate, glyceryl monostearate, and stearic acid were used to prepare the dropping pills. X-ray powder diffraction, differential scanning calorimetry, and release were used to evaluate its physicochemical properties. The plasma concentration of silybin in beagle dogs after oral administration of silymarin dropping pills and silymarin capsule was determined by RP-HPLC.

Results: Synchronized release was achieved with high similarity factor f2 values between every set of two of the five components. Mean plasma concentration-time curves of silymarin after oral administration of dropping pills in beagle dogs were in accordance with first-order absorption and open twocompartment model. The Tmax, Cmax, and AUC0-∞ of dropping pills in beagle dogs were 0.8750±0.13 h, 0.8183±0.07 μg·ml-1, and 2.274±0.90 μg·h·ml-1, respectively. Silymarin dropping pills prolonged in vivo exposure and reduced maximum in vivo concentration, achieving a stable level in the serum.

Conclusion: The combination of solid dispersion technique and dropping pill formulation allowed synchronized release of multiple components in herbal medicine, and has potential application in the development of sustained release in herbal medicine.

Cite this article as:

Liu Zhi-hong, Li Xue-jing, Huang Ai-wen, Zhang Jing and Song Hong-tao*, Preparation and Characterization of Silymarin Synchronized and Sustained Release Dropping Pill, Current Drug Delivery 2017; 14 (5) . https://dx.doi.org/10.2174/1567201814666170213154043

DOI https://dx.doi.org/10.2174/1567201814666170213154043	Print ISSN 1567-2018
Publisher Name Bentham Science Publisher	Online ISSN 1875-5704