Introduction: Modified quinolines have been used as metal chelators, and they have drawn
the attention of researchers due to the possible biological approaches with a broad scope of application.
This study aims to evaluate the in vitro biological effects of seven quinolinic compounds in RAW
macrophage culture, blood cells and in Candida albicans fungus.
Methods: Cell viability and proliferation of macrophages were evaluated using trypan blue and MTT
staining assays. Gene expression was analyzed through RT-qPCR. Hematological analysis was carried
out using flow cytometry and coagulogram tests. The analysis of Candida albicans strains was performed
through the Minimum Inhibitory Concentration test (MIC).
Results: The compounds did not significantly interfere with cell viability and proliferation of macrophages;
however, compounds 6 and 7 increased the expression of both TNF-α and TGF-β1. Compound
3, in turn, only increased the expression of TNF-α and compound 4 increased TGF-β1 expression.
Conclusion: There were significant alterations in blood cellularity and in human coagulation cascade.
Nevertheless, no fungicidal or fungistatic effect could be observed regarding Candida albicans.