Tissue Engineering and Regenerative Medicine Potentialities of Materials - Based Novel Constructs - A Review

Author(s): Hafiz M.N. Iqbal*, Kuldeep Dhama, Ashok Munjal, Rekha Khandia, Kumaragurubaran Karthik, Maryam Dadar, Swati Sachan, Shyma K. Latheef, Sunil K. Joshi.

Journal Name: Current Regenerative Medicine (Under Re-organization)

Volume 6 , Issue 1 , 2016

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Abstract:

Background: In recent years, tissue engineering (TE) and regenerative medicine (RM) are rapidly evolving fields. TE and RM are part of the biomedical field, and both are emergent research areas with a high impact on medical issues. The development of new types of novel, effective and highly reliable engineering constructs is essential to tackle many human health-related diseases. To this end, materials science technology offers an excellent engineering exploitability.

Objective: The objective of this review is to extend the current knowledge in the field of biomaterials for TE and RM including human-made novel constructs though using different materials and strategies.

Methods: We extensively reviewed, analyzed and compiled salient information from the authentic published literature available in PubMed and other scientific databases.

Results: The multi-shape novel constructs have been fabricated for a variety of applications in bio and non-bio sectors of the modern world. As compared to the natural bulk material, engineering of their constructs particularly at the micro and nano-level impart unique characteristics including surface area and surface functionality enhancement, improved thermo-mechanical and electrical conductivity, etc. The materials-based engineered constructs have been exploited in biotechnology at large and biomedical in particular.

Conclusion: The most promising applications include their utilization as a vehicle to deliver therapeutic agents, as scaffolds for engineering various tissues and also serve as an integrated part of biomedical implants, etc. Herein, we reviewed bio-nano-technological advancements from a TE and RM perspective in particular and envision directions of future developments.

Keywords: Biomaterials, bone tissue engineering, heart tissue engineering, novel constructs, organs, regeneration, skin tissue engineering, tissue engineering.

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Article Details

VOLUME: 6
ISSUE: 1
Year: 2016
Page: [29 - 40]
Pages: 12
DOI: 10.2174/2468424407666170210144332
Price: $58

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