When Good Goes Awry: The Aggregation of Protein Therapeutics

Author(s): Jennifer M. Redington, Leonid Breydo, Vladimir N. Uversky.

Journal Name: Protein & Peptide Letters

Volume 24 , Issue 4 , 2017

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Abstract:

Protein therapeutics are playing an increasingly important role in treatment of a variety of human diseases. However, like the rest of proteins, they are susceptible to aggregation. Aggregation of proteinaceous pharmaceuticals can cause a loss of efficacy and, potentially, cytotoxicity and an immunogenic response. This review describes various ways protein therapeutics aggregate and a variety of approaches taken to prevent or minimize this process.

Keywords: Aggregation, formulation, storage, delivery, insulin, glucagon, antibodies

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Article Details

VOLUME: 24
ISSUE: 4
Year: 2017
Page: [340 - 347]
Pages: 8
DOI: 10.2174/0929866524666170209153421
Price: $58

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