Solid-State Structure of Abeta (Aβ) in Alzheimer's Disease

Author(s): Jun-Xia Lu, Xing-Qi Dong, Jian-Jun Zhang.

Journal Name: Protein & Peptide Letters

Volume 24 , Issue 4 , 2017

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Abstract:

Alzheimer’s disease (AD) has become the most common neurodegenerative disease. The deposition of amyloid fibrils in the brain is one of the characteristics of AD. The fibrils are composed of amyloid-β peptide (Aβ). Aβ is produced through a series event of protease cleavage of a transmembrane protein called β-amyloid precursor protein (APP) which is commonly expressed in the brain. The production of Aβ and its propensity to aggregation to form oligomers and fibrils are believed to initiate a sequence of events that lead to AD dementia. The production of Aβ is influenced by the transmembrane domain (TM) structure of APP. The structure variety of different Aβ assemblies including oligomers and fibrils may result in different neurotoxicity to the brain. Therefore, enormous work has been carried out to study the structure of APP TM and various Aβ assemblies. Solid-state NMR has advantages in studying immobile protein structures with large molecular weight. In this review, solid-state NMR structure of APP TM and different Aβ assemblies will be discussed, especially various Aβ amyloid fibril structures. This structural information greatly enhanced our understanding in AD, providing fundamental knowledge that will help in finding a treatment for AD.

Keywords: Alzheimer's disease, amyloid precursor protein, amyloid-β peptide, amyloid fibrils, oligomers, solid-state NMR.

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Article Details

VOLUME: 24
ISSUE: 4
Year: 2017
Page: [322 - 330]
Pages: 9
DOI: 10.2174/0929866524666170208155108
Price: $58

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