Background: The design and performing of cascade reactions is a challenging but stimulating and
interesting facet of organic synthesis, yet one that can convey conspicuous novelty, efficiency as well as elegance
and sophistication to synthetic approaches. On the other hand, isocyanides are well-recognized as privileged
synthons in the synthesis of a wide range of heterocycles.
Objective: In this review, we try to illustrate the power, efficiency, and convenience of combining cascade
process as an expedient strategy with versatility of isocyanide-based multicomponent reactions in the synthesis
of aza-heterocycles from 1993 till date. Comprising isocyanides in cascade or sequential pathway also
represents a milestone in combinatorial chemistry which is a bounce for this contented marriage.
Keywords: Isocyanides, isonitriles, cascade reactions, tandem reactions, domino reactions, ugi reactions, aza-heterocyclic compounds.
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