Background: Alzheimer's disease (AD) is the most common and well-studied neurodegenerative
disease (ND). Biological pathways, pathophysiology and genetics of AD show commonalities with
other NDs viz. Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington's disease
(HD), Prion disease and Dentatorubral-pallidoluysian atrophy (DRPLA). Many of the NDs, sharing the
common features and molecular mechanisms suggest that pathology may be directly comparable and be
implicated in disease prevention and development of highly effective therapies.
Method: In this review, a brief description of pathophysiology, clinical symptoms and available treatment
of various NDs have been explored with special emphasis on AD. Commonalities in these fatal
NDs provide support for therapeutic advancements and enhance the understanding of disease manifestation.
Conclusion: The studies concentrating on the commonalities in biological pathways, cellular mechanisms
and genetics may provide the scope to researchers to identify few novel common target(s) for disease
prevention and development of effective common drugs for multi-neurodegenerative diseases.