Background: Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that
gradually degrades neuronal cells. It is the most frequent cause of memory loss and dementia in elderly individuals
worldwide. The extracellular deposition of beta amyloid (Aβ), intracellular neurofibrillary tangles (NFTs) retention,
neuronal decline and neurotransmitter system derangement are the patho-physiological marker of this devastated
Objective: In view of limited treatment option and their success rate, there is an urgent need to explore the vast array
of proteomes for the management of AD. These proteins could be therapeutically targeted to prevent the progression
of this disease. In the present review, we tried to uncover several proteins that could be exploited in AD therapeutics.
Conclusion: Based on our article, we conclude that proteome based AD treatment needs more refinements and
approaches to achieve the desired success rate.