The decline of tissue function in ageing is a consequence of many changes in the gene expression
and other extrinsic factors. The molecular mechanisms underlying these changes are heavily
investigated with focus on regulation of time-lapse gene expression. microRNAs, short non-coding
RNA molecules, are among the major regulators of gene expression. microRNAs have been shown to
control ageing-related mechanisms and several evidences suggest age-related changes in microRNA
transcriptome. However, the source regulator of time-lapse gene expression control still remains unknown.
Here, we have reviewed microRNA molecules related to the ageing of bones and studies that
investigated age-related bone tissue gene expression. We identified 41 microRNA molecules from the
literature that correlate with bone mineral density or fractures and one recent study has demonstrated
how a combination of several microRNAs can be used for better prediction of the fractures in osteoporotic
patients. The personalised diagnostic algorithms in the future should be therefore based on the
combination of multiple biomarkers. Until now, little is known about the regulatory mechanisms of
microRNA expression and genes in ageing. We have proposed a link between telomere length and
gene expression profiles, however this now needs to be further investigated.
Keywords: Telomere, gene expression, epigetic biomarkers, personalised diagnostics, osteoporosis, age-related musco-skeletal
Rights & PermissionsPrintExport