Microwave-induced Triazole Synthesis via 1,3-dipolar azide-alkyne cycloaddition: Recent Advances

Author(s): Sujit Ghosh, Basudeb Basu*.

Journal Name: Current Green Chemistry

Volume 3 , Issue 3 , 2016

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Abstract:

Background: 1,3-Dipolar azide-alkyne cycloaddition (AAC) reaction, often referred to as click reaction, is an expeditious and robust protocol for the construction of triazole derivatives. In most cases, the reaction is catalyzed by a copper catalyst.

Methods: Non-conventional microwave heating has been used for the reaction showing ample advantages over the conventional thermal heating.

Conclusion: This article has presented an overview on the recent advances in the area of microwave- induced AAC reactions in the presence of both homogeneous and heterogeneous copper catalysts, besides a few examples of Ru-catalyzed as well as metal-free AAC reactions.

Keywords: Azide-alkyne cycloaddition (AAC), microwave irradiation (MW), 1, 2, 3-triazole, regioisomer, copper catalyst, metal-free, triazole synthesis.

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2016
Page: [195 - 213]
Pages: 19
DOI: 10.2174/2213346104666170130143600
Price: $58

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