Background: In spite of the fact that there are numerous reagents and methods to synthesize
the dihydropyrimidinones via Biginelli reaction, but excellent yields, shorter reaction time and easy
work-up are important factors which are not usually found together in a chemical reaction. This work
aims to introduce a new reagent with above-mentioned capabilities in mild reaction conditions.
Methods: With the benefit of NaHSO4 ionic liquid immobilized on silica as reusable heterogeneous
catalyst, prepared via sol-gel method and characterized by SEM and XRD techniques, we could synthesize
dihydropyrimidinones derivatives in mild conditions.
Results: Data obtained from different identifying techniques, such as SEM and XRD for characterization
of the structure of catalyst, and also IR, NMR and Mass spectroscopic techniques for characterization
of products obviously confirm the efficacy and integrity of the method.
Conclusion: In conclusion, the present procedure provides an efficient reagent for the synthesis of
Biginelli compounds. Mild reaction conditions, ease in work-up, high yields, stability and recyclability
of the reagent are features of this new procedure.