1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities
and attracting the researchers to work on this nucleus. Literature survey indicates that many 1,3,4-
oxadiazoles have been synthesized with the aim to get compounds of significant anti-inflammatory
and analgesic activities with reduced adverse effects. The purpose of this review is to compile the
reports on 1,3,4-oxadiazole derivatives possessing anti-inflammatory and analgesic activities. The
review also includes the reports on 1,3,4-oxadiazole derivatives of existing NSAIDs in the last ten
Keywords: Analgesic, anti-inflammatory, scaffold, COX, 1, 3, 4-Oxadiazole, NSAIDs.
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