The association between type 2 diabetes mellitus (T2DM) and systemic inflammation may
increase platelet reactivity and the accelerated development of vascular disease. Platelets are able to
modulate the function of immune cells via the direct release of growth factors and pro-inflammatory
chemokines through the production of microvesicles. The microvesicles trigger a transcellular delivery
system of bioactive molecules to other cells acting as vectors in the exchange of biological information.
Here, we consider the influence of platelets and platelet-derived microvesicles on cells of the immune
system and the implications in the pathogenesis of T2DM.
Keywords: Platelets, microvesicles, immune, effectors, diabetes, inflammation.
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