Platelets and Platelet-Derived Microvesicles as Immune Effectors in Type 2 Diabetes

Author(s): Nancy Cortez-Espinosa, Laura Perez-Campos Mayoral*, Eduardo Perez-Campos, Hector Alejandro Cabrera Fuentes, Eduardo Perez-Campos Mayoral, Ruth Martínez-Cruz, Socorro Pina Canseco, Gabriel Mayoral Andrade, Margarito Martinez Cruz, Itandehui Gallegos Velasco, Pedro Hernandez Cruz.

Journal Name: Current Vascular Pharmacology

Volume 15 , Issue 3 , 2017

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Abstract:

The association between type 2 diabetes mellitus (T2DM) and systemic inflammation may increase platelet reactivity and the accelerated development of vascular disease. Platelets are able to modulate the function of immune cells via the direct release of growth factors and pro-inflammatory chemokines through the production of microvesicles. The microvesicles trigger a transcellular delivery system of bioactive molecules to other cells acting as vectors in the exchange of biological information. Here, we consider the influence of platelets and platelet-derived microvesicles on cells of the immune system and the implications in the pathogenesis of T2DM.

Keywords: Platelets, microvesicles, immune, effectors, diabetes, inflammation.

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Article Details

VOLUME: 15
ISSUE: 3
Year: 2017
Page: [207 - 217]
Pages: 11
DOI: 10.2174/1570161115666170126130309
Price: $58

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