Ultrasound-Assisted 3-Component Reaction in Acetic Acid Alone: Catalyst / Promoter / Ligand Free Synthesis of Bioactive Pyrazolo[1,5-a]pyrimidines

Author(s): Namburi Suresh, Bodapati Veera Durgarao, A. Ratnakar, Sunder Kumar Kolli, Mohd Ashraf Ashfaq, Mandava V. Basaveswara Rao*, Manojit Pal*.

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 10 , 2017

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Graphical Abstract:


Background: Acetic acid alone when employed as a solvent under ultrasound irradiation has been found to be effective for the three-component reaction involving ethyl-5- amino-1H-pyrazole-4-carboxylate, aromatic aldehydes and terminal alkynes in the presence of aerial oxygen.

Methods: The catalyst / promoter / ligand free method afforded a range of pyrazolo[1,5-a] pyrimidines as potential and new cytotoxic agents.

Results and Conclusion: While some of these compounds showed cytotoxicities against two breast cancer cell lines one of them was found to be promising.

Keywords: Ultrasound, MCR, acetic acid, pyrazolo[1, 5-a]pyrimidine, drug discovery, anti-tumor.

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Article Details

Year: 2017
Page: [1176 - 1183]
Pages: 8
DOI: 10.2174/1570180814666170126120408
Price: $58

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