Background: Acetic acid alone when employed as a solvent under ultrasound
irradiation has been found to be effective for the three-component reaction involving ethyl-5-
amino-1H-pyrazole-4-carboxylate, aromatic aldehydes and terminal alkynes in the presence of
Methods: The catalyst / promoter / ligand free method afforded a range of pyrazolo[1,5-a]
pyrimidines as potential and new cytotoxic agents.
Results and Conclusion: While some of these compounds showed cytotoxicities against two
breast cancer cell lines one of them was found to be promising.
Keywords: Ultrasound, MCR, acetic acid, pyrazolo[1, 5-a]pyrimidine, drug discovery, anti-tumor.
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