Ultrasound Assisted Synthesis of 2-alkynyl Pyrazolo[1,5-a]pyrimidines as Potential Anti-cancer Agents

Author(s): Yarlagadda Bharath, Mandava V. Basaveswara Rao*, Manojit Pal*.

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 10 , 2017

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Abstract:

Background: The 2-alkynyl pyrazolo[1,5-a]pyrimidine derivatives have been explored as new and potential anti-proliferative agents.

Methods: Ultrasound assisted synthesis of these compounds was carried out by using a multi-step method involving the H3PO3 mediated construction of pyrazolo[1,5-a]pyrimidine ring possessing a bromo group at C-2 position followed by Pd/C-Cu catalyzed alkynylation methodology as the key steps.

Results and Conclusion: All these compounds showed selective growth inhibition of cancer cell lines when tested against MDA-MB 231 and K562 cell lines along with non-cancerous HEK293 cells.

Keywords: Pyrazolo[1, 5-a]pyrimidine, Pd/C, coupling, ultrasound, cancer, anticancer agents.

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Article Details

VOLUME: 14
ISSUE: 10
Year: 2017
Page: [1206 - 1214]
Pages: 9
DOI: 10.2174/1570180814666170125125654
Price: $58

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