Update on Predicting Severe Hyperbilirubinemia and Bilirubin Neurotoxicity Risks in Neonates

Author(s): Pearl W. Chang*, Thomas B. Newman, M. Jeffrey Maisels.

Journal Name: Current Pediatric Reviews

Volume 13 , Issue 3 , 2017

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Abstract:

Extreme hyperbilirubinemia and kernicterus, though rare, continue to occur despite the adoption of universal screening. Unless they are known to have glucose-6-phosphate dehydrogenase deficiency, infants who currently develop kernicterus in high resource countries are often otherwise healthy newborns discharged from the well-baby nursery. In this review, we highlight risk factors that increase the risk of a newborn ≥35 weeks gestational age developing severe hyperbilirubinemia, as well as the risk factors that increase the hyperbilirubinemic infant’s risk of kernicterus.

Keywords: Hyperbilirubinemia, jaundice, neonates, kernicterus, neurotoxicity, phototherapy.

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Article Details

VOLUME: 13
ISSUE: 3
Year: 2017
Page: [181 - 187]
Pages: 7
DOI: 10.2174/1573396313666170123151408
Price: $58

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