Functional Peptides from Laminin-1 Improve the Cell Adhesion Capacity of Recombinant Mussel Adhesive Protein

Author(s): Kai Wang, Lina Ji, Zichun Hua.

Journal Name: Protein & Peptide Letters

Volume 24 , Issue 4 , 2017

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Graphical Abstract:


Since cell adhesion is important for cell processes such as migration and proliferation, it is a crucial consideration in biomaterial design and development. Based on the fusion of mussel adhesive protein fp151 with laminin-1-originated functional peptides we designed fusion proteins (fLA4, fLG6 and fAG73) and explored their cell adhesion properties. In our study, cell adhesion analysis showed that protein fLG6 and fLA4 had a significantly higher cell adhesion property for A549 than fp151. Moreover, protein fAG73 also displayed a strong adhesion capacity for Hela cells. In conclusion, the incorporation of functional peptides with integrin and heparin/heparan sulphate binding capacity into mussel adhesive protein will promote the application of mussel adhesive protein as cell adhesion biomaterial.

Keywords: Cell adhesion materials, functional peptides, heparin/heparan sulfate binding peptide, integrin binding peptides, mussel adhesive protein.

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Article Details

Year: 2017
Page: [348 - 352]
Pages: 5
DOI: 10.2174/0929866524666170123142225
Price: $58

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PDF: 12