Brain Gangliosides in Alzheimer’s Disease: Increased Expression of Cholinergic Neuron-Specific Gangliosides

Author(s): Yuki Fukami, Toshio Ariga, Mitsunori Yamada, Nobuhiro Yuki*.

Journal Name: Current Alzheimer Research

Volume 14 , Issue 6 , 2017

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Abstract:

Background: Gangliosides are enriched in the neuronal membranes. Gangliosides are shown to interact with amyloid-β proteins, leading to formation of amyloid fibrils in Alzheimer’s disease (AD) brains. Several earlier studies indicated that the alterations of ganglioside metabolism could contribute the pathogenesis of AD.

Methods: Gangliosides were isolated from the frontal lobes in five patients with AD and three control subjects. Gangliosides were assessed by high performance thin-layer chromatography (HPTLC) with resorcinol staining and immunostaining using mouse monoclonal antibodies against cholinergic neuronspecific (Chol-1α) gangliosides.

Results: In all AD brains, not only the total sialic acid content but also a-series gangliosides, GM1 and GD1a, were dramatically reduced as compared with those in control subjects. These results are a hallmark of the pathogenesis in AD. In contrast, Chol-1α gangliosides, GT1aα and GQ1bα, which are specific markers of cholinergic neurons, were significantly increased in AD brains.

Conclusion: The expression of Chol-1α gangliosides may be caused by a compensation to preserve the function of the cholinergic neuron and play an important role in cholinergic synaptic transmission.

Keywords: Alzheimer's disease, Chol-1α antigen, cholinergic neuron, ganglioside, dementia.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2017
Page: [586 - 591]
Pages: 6
DOI: 10.2174/1567205014666170117094038
Price: $58

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