Fever or Pyrexia means abnormal rise in body temperature above the usual range of normal in response to a
variety of infectious, immunological and neoplastic stimuli. To normalize these febrile conditions, several synthetic
agents are in clinical practice such as acetaminophen, ibuprofen, and aspirin. However, they are having many side
effects which sometimes challenge their applications. The various sources are under investigation worldwide to overcome
issues of unwanted effects and to better therapeutic response. In this scenario botanicals such as alkaloids, the
most widely distributed and studied plant secondary metabolites, could effectively produce the molecules with better
antipyretic effect and safety profile. The current review deals with 21 isolated alkaloids from 14 plants species having
some antipyretic effect in preliminary screening/preclinical studies with the possible mechanism and structural edges.
Therefore, these alkaloids of plant origin are candidates for further detail studies to ascertain their mechanism(s) and
clinical utility or as lead compounds for future drugs.