Abstract
Background & Aim: Photosensitizers are key molecules used in photodynamic cancer therapy (PDT), which is an effective therapeutic modality option for several diseases and nononcological disorders. Due to its lower systemic toxicity and its ability to destroy tumors selectively, PDT has been considered as clinical avenue for the treatment of several cancers.
Methods & Results: Three essential elements are involved in a PDT procedure: a photosensitizer, light of a specific wavelength, and singlet oxygen. However, the properties of conventional photosensitizers exhibit some drawbacks that may limit their use. Nanoparticles can provide significant benefits that counter these drawbacks and enable higher efficiency and biosafety. With the development of nanotechnology, nanoparticles have been used to encapsulate photosensitizers to enhance the phototoxic and pharmacokinetic properties of these agents. Conclusion: Here, the main motivation for this review is to summarize recent progress in the development of photosensitizers, in particular, photosensitizers with nanoparticle modifications. In addition, we reviewed the clinical treatment of several diseases using photosensitizers formulated with nanoparticles, with the overall goal of aiding the design and development of novel photosensitizers.Keywords: Photosensitizer, nanoparticle, photodynamic therapy, cancer, non-oncological disorders, clinical treatment.
Combinatorial Chemistry & High Throughput Screening
Title:Recent Advances in Developing Photosensitizers for Photodynamic Cancer Therapy
Volume: 20 Issue: 5
Author(s): Cong Chen, Jianmin Wang, Xiaoyan Li, Xiaolong Liu and Xiao Han*
Affiliation:
- Biotechnology Research Institute, Chinese Academy of Agricultural Sciences. Beijing 100176,China
Keywords: Photosensitizer, nanoparticle, photodynamic therapy, cancer, non-oncological disorders, clinical treatment.
Abstract: Background & Aim: Photosensitizers are key molecules used in photodynamic cancer therapy (PDT), which is an effective therapeutic modality option for several diseases and nononcological disorders. Due to its lower systemic toxicity and its ability to destroy tumors selectively, PDT has been considered as clinical avenue for the treatment of several cancers.
Methods & Results: Three essential elements are involved in a PDT procedure: a photosensitizer, light of a specific wavelength, and singlet oxygen. However, the properties of conventional photosensitizers exhibit some drawbacks that may limit their use. Nanoparticles can provide significant benefits that counter these drawbacks and enable higher efficiency and biosafety. With the development of nanotechnology, nanoparticles have been used to encapsulate photosensitizers to enhance the phototoxic and pharmacokinetic properties of these agents. Conclusion: Here, the main motivation for this review is to summarize recent progress in the development of photosensitizers, in particular, photosensitizers with nanoparticle modifications. In addition, we reviewed the clinical treatment of several diseases using photosensitizers formulated with nanoparticles, with the overall goal of aiding the design and development of novel photosensitizers.Export Options
About this article
Cite this article as:
Chen Cong, Wang Jianmin, Li Xiaoyan, Liu Xiaolong and Han Xiao*, Recent Advances in Developing Photosensitizers for Photodynamic Cancer Therapy, Combinatorial Chemistry & High Throughput Screening 2017; 20 (5) . https://dx.doi.org/10.2174/1386207320666170113123132
DOI https://dx.doi.org/10.2174/1386207320666170113123132 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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