Obstructive sleep apnea-hypopnea syndrome (OSAHS) is normally linked to cognitive and
functional dysfunctions. In this study, we explored the resting-state functional connectivity (rsFC) in the
default mode network (DMN) to show the mechanism of neurophysiology in patients with OSAHS.
Resting-state structural and functional Magnetic Resonance Imaging (fMRI) data were obtained from
sixteen male moderate-to- severe patients with untreated OSAHS and 15 male matched healthy control
subjects. The rsFC in the DMN was analyzed between OSAHS and healthy controls by the CONN
software. Compared with the controls, the rsFC showed a significant decrease in the medial prefrontal
cortex, anterior cingulate and posterior cingulate, and showed an increase in the left inferior parietal
lobule in OSAHS patients. The results indicated that the OSAHS patients presented alternatives of rsFC
in the DMN compared with the controls.
Keywords: CONN, default mode networks, obstructive sleep apnea-hypopnea syndrome, resting-state functional connectivity.
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