Coumarin derivatives play an important role in many different biomedical and technological applications.
As “privileged” scaffolds, coumarin derivatives display interesting biological and important optoelectronic
properties. The practical significance of coumarin molecules has encouraged extensive efforts toward their synthesis.
Although classical methods, such as the Perkin, Pechmann and Knoevenagel reactions for the synthesis of
a wide variety of substituted coumarins, are still actively used, these methods suffer several limitations. Nowadays,
alternative new efficient syntheses of coumarin derivatives are constantly evolving and being of
considerable interest. The hydroarylation reaction of alkynes, using transition metals catalysts, is considered one
of the most prospective tools for rapid accessing to coumarin scaffolds in an efficient and atom-economical
manner. This coumarin construction could be achieved through inter- or intramolecular reactions of respective
phenols and alkynes or aryl alkynoates. The present review mainly covers recent studies on new methods for the
synthesis of coumarin derivatives via alkenylation of phenols with alkynes, aryl alkynoates and related reagents
or direct functionalization of alkynoates. The information provided should furnish a fresh insight for organic
chemists in the design of novel molecules that contain the coumarin skeletons.
Keywords: Functionalized coumarins, hydroarylation reactions, C-C bond formation, alkynoates, transition-metal-catalyzed process, direct
intramolecular alkyne functionalization.
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