Cancer is the leading cause of morbidity and mortality worldwide. Therefore, the search
for new and less aggressive treatments is currently the focus of the anticancer research. An attractive
alternative for this purpose is the use of bioactive peptides from plants. Plants live everywhere on
Earth, both on land and in water, and they are a major source of diverse molecules with pharmacological
potential as antioxidant peptides. Hence, this review focuses on the importance of the antioxidant
activity of terrestrial and aquatic plant peptides against cancer throughout several mechanisms.
The influence of the antioxidant activity of peptides by different factors such as molecular weight and
amino acid composition as a crucial factor for anticancer activity is also revised. Furthermore, the relation
of antioxidant activity with anticancer property as well as safety and legal aspects of protein
hydrolysates and bioactive peptides for their use in cancer treatments is discussed.
Keywords: Antioxidant, anticancer, hydrolysates, peptides, terrestrial plants, aquatic plants.
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