Since the discovery of SUMOs (small ubiquitin-like modifiers)
over 20 years ago, sumoylation has recently emerged as an important posttranslational
modification involved in almost all aspects of cellular
physiology. In neurons, sumoylation dynamically modulates protein function
and consequently plays an important role in neuronal maturation, synapse
formation and plasticity. Thus, the dysfunction of sumoylation pathway is
associated with many different neurological disorders. Hundreds of different
proteins implicated in the pathogenesis of neurological disorders are
SUMO-modified, indicating the importance of sumoylation involved in the
neurological diseases. In this review, we summarize the growing findings on protein
sumoylation in neuronal function and dysfunction. It is essential to have a thorough
understanding on the mechanism how sumoylation contributes to neurological diseases in
developing efficient therapy for these diseases.
Keywords: Sumoylation, neurological diseases, neuronal function, synapse formation.
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