Sumoylation, a post-translational modification discovered over a
decade ago, turns out to be a very important regulatory mechanism
mediating multiple cellular processes. Recent studies from our laboratory
and others also revealed that it plays a crucial role in regulating both
differentiation and pathogenesis of the ocular lens. This review will
summarize these progresses.
Keywords: Lens, sumoylation, differentiation, cataractogenesis, pathogenesis.
Rights & PermissionsPrintExport