Current Molecular Medicine

David W. Li  
College of Medicine
University of Nebraska Medical Center
Omaha, NE
USA

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Sumoylation in Lens Differentiation and Pathogenesis

Author(s): J.-W. Xiang, Z.-G. Chen, L. Gong, Y. Xiao, W.-J. Qing, L. Wang, X.-H. Hu, Z.-X. Huang, R.-L. Qi, T.-H. Yang, A.-P. Arrigo, L. Zhang, X.-C. Tang, S. Huang, F.-Y. Liu, Z.-W. Luo, Y.-F. Liu, Q. Sun, J. Gigantelli, Y.-Z. Liu, D. W.-C. Li.

Abstract:

Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.

Keywords: Lens, sumoylation, differentiation, cataractogenesis, pathogenesis.

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Article Details

VOLUME: 16
ISSUE: 10
Year: 2016
Page: [859 - 870]
Pages: 12
DOI: 10.2174/1566524017666170109123238
Price: $58