Background: Neoflavonoids comprise a group of compounds that have a C6-C3-C6 carbon
skeleton and that naturally occur in higher plants from families Clusiaceae, Leguminosae, Rubiaceae,
Passifloraceae, Asteraceae and Rutaceae.
Objective: Neoflavonoids have drawn great interest lately due to their pharmacological and biochemical
properties found in vitro and in vivo studies, which is attributed to the pattern of substitutions found in
their basic chemical structure.
Methods: This review was prepared by analyzing articles selected from Science Direct, Scopus, Pub
Med, Web of Science and SciFinder.
Results: Among other pharmacological activities, in vitro and in vivo studies have highlighted these
compounds as promising bioactive molecules in the treatment of some parasitic neglected tropical infections
(NTIs) such as malaria, leishmaniasis and American trypanosomiasis (Chagas Disease). Neoflavonoids
have also showed activity against HIV-1 (human immunodeficiency virus type 1), and have
been used to develop new molecules for the treatment of HIV/AIDS.
Conclusion: Therefore, a more intensive research of neoflavonoids can provide inputs to discover and
develop alternative therapies from new bioactive molecules. Thus, this review summarizes the results of
studies involving neoflavonoids and their derivatives with therapeutic implications in the treatment of
NTIs and HIV.