Background: Magnocellular neurosecretory neurons of the hypothalamic supraoptic (SON)
and paraventricular (PVN) nuclei synthesize vasopressin and oxytocin in response to signals generated by
osmoreceptors and baroreceptors and, respectively, by receptors of the nipples and cervix.
Methods: We analyzed the literature identifying relevant articles dealing with synaptic inputs of neural
afferent pathways to Vasopressin-and Oxytocin-secreting neurons of SON and PVN.
Results: This article focuses on the multisynaptic pathways involved in the regulation of Vasopressin and
Conclusion: An updated topographic description of the afferent pathways involved in the regulation of
VPergic and OTergic neurons and their synaptic inputs inducing the stimulus-secretion-coupling has been
Keywords: Circumventricular organs, forebrain and brainstem afferent pathways, nucleus tracti solitarii, oxytocin, supraoptic
and paraventricular magnocellular neurons, synaptic inputs, vasopressin.
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