Alzheimer’s disease (AD), which largely affects the elderly, has become a global burden. Patients
with AD have both short- and long-term memory impairments. The neuronal loss in AD occurs
due to abnormally folded amyloid beta proteins and aggregation of hyperphosphorylated tau proteins in
the brain. Eventually, amyloid plaques and neurofibrillary tangles are formed, which subsequently disintegrate
the neuronal transport system. There are several factors which are involved in AD pathogenesis,
including oxidative stress, inflammation and the presence of metal ions. The modern therapies utilized
for AD treatment have many adverse effects, driving the quest for more safe and effective medications.
Many dietary components, including different types of fruits, vegetables, spices, and marine products as
well as a Mediterranean diet, are a good source of antioxidants and have anti-inflammatory properties,
with many showing substantial potential against AD pathogenesis. In this review, we discuss the potential
of these foods for treating AD and opportunities for developing disease-targeted drugs from active
compounds extracted from natural dietary products.
Keywords: Alzheimer's disease, Natural products, Fruits, Spices, Vegetables, Drinks, Mediterranean diet, Treatment.
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